NAD+
Coenzyme researched for cellular energy and longevity.
NAD+
Background
Nicotinamide adenine dinucleotide (NAD+) is an endogenous coenzyme central to cellular redox reactions and a substrate for enzymes including sirtuins and PARPs. Research interest focuses on the decline of NAD+ with age and the effects of restoring NAD+ pools on mitochondrial function, DNA repair, and metabolic regulation.
The field is active and rapidly evolving, with most mechanistic evidence drawn from cellular and animal models; human trials of NAD+ precursors are ongoing and results are mixed.
Selected literature
- Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism. 2018;27(3):529-547.
- Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021;22(2):119-141.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213.
References are provided for scientific context only. Citation does not imply endorsement of any use, nor a claim of safety or efficacy. Findings frequently derive from in-vitro or animal models.
Trademarks & attribution
Nicotinamide adenine dinucleotide is a naturally occurring endogenous coenzyme and is not a trademarked product. Supplied as reference material only.
