MOTS-c
Lyophilized research reference material. Released with a per-lot Certificate of Analysis. For laboratory research use only.
- All products currently listed on this site are for research purposes ONLY.
- All products sold on this website are intended for research and identification purposes only.
- These products are not intended for human dosing, injections, or ingestion.
- Peptides are strictly for laboratory, academic, or institutional research and not for human or animal consumption.
Research background
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. Research describes it as a regulator of metabolic homeostasis, with proposed actions on the AMPK pathway and translocation to the nucleus under metabolic stress.
The evidence base is primarily cellular and rodent; MOTS-c is a research compound without an approved indication.
Summary of published scientific literature provided for laboratory research reference only. It is not a claim of safety, efficacy, or suitability for any use, and does not describe or recommend any human or veterinary use.
Selected references
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. Nature Communications. 2021;12:470.
- Kim KH, Son JM, et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus. Cell Metabolism. 2018;28(3):516-524.
Trademarks & attribution
MOTS-c is an endogenously encoded mitochondrial-derived peptide with no registered pharmaceutical trademark or approved drug product. Supplied as reference material only.
