KPV
Lyophilized research reference material. Released with a per-lot Certificate of Analysis. For laboratory research use only.
- All products currently listed on this site are for research purposes ONLY.
- All products sold on this website are intended for research and identification purposes only.
- These products are not intended for human dosing, injections, or ingestion.
- Peptides are strictly for laboratory, academic, or institutional research and not for human or animal consumption.
Research background
KPV is the C-terminal tripeptide (lysine-proline-valine) of alpha-melanocyte-stimulating hormone. It has been studied for activity in inflammation models that appears independent of melanocortin receptors, with proposed intracellular actions on NF-κB signaling and uptake via the peptide transporter PepT1 in intestinal epithelium.
Preclinical models of colitis and inflammation form the bulk of the evidence; KPV is a research compound without an approved indication.
Summary of published scientific literature provided for laboratory research reference only. It is not a claim of safety, efficacy, or suitability for any use, and does not describe or recommend any human or veterinary use.
Selected references
- Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178.
- Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases. 2008;14(3):324-331.
- Brzoska T, et al. Alpha-MSH and related tripeptides. Endocrine Reviews. 2008;29(5):581-602.
Trademarks & attribution
KPV is the C-terminal tripeptide fragment of alpha-MSH and has no registered pharmaceutical trademark or approved drug product. Supplied as reference material only.
